Dr. Peter Crino, MD, PhD

Dr. Crino's laboratory is interested in understanding how aberrant development of the cerebral cortex contributes to pervasive neurological disorders such as epilepsy, mental retardation, and autism. Specifically, we are studying the molecular pathogenesis of cortical dyslamination in a variety of syndromes associated with these disorders including focal cortical dysplasia, heterotopias, tuberous sclerosis, and hemimegalencephaly.

Dr. David Louis, MD

Dr. Louis' laboratory studies the molecular genetic basis of human brain tumors, both common sporadic brain tumors as well as rarer, inherited brain tumor syndromes. Most of the work has focused on malignant gliomas. The laboratory was the first to demonstrate that molecular genetic analysis could be used to divide glioblastomas into clinicopathologically distinct genetic subsets. The laboratory has also shown that specific genetic alterations are powerful predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. Recent work has focused on the effects of chemotherapy on malignant glioma genotype at the time of recurrence.