Dr. Brendan Manning, PhD

Brendan Manning, PhD, is an Assistant Professor of Genetics and Complex diseases at Harvard School of Public Health. The research in his laboratory is aimed at characterizing biochemical links between cellular signaling pathways involved in tumor development and those controlling central metabolism. The goal of this research is to understand the role of oncogenes and tumor suppressors in coordinating cellular signaling events propagated by growth factors, the availability of energy and nutrients, and exposure to environmental stresses. The ability to properly perceive and integrate these signals at both the cellular and organismal levels is essential for the prevention of tumorigenesis and the maintenance of metabolic homeostasis. He is particularly interested in pathways controlling and controlled by the products of the tumor suppressor genes, TSC1 and TSC2, understood to be mutated in tuberous sclerosis complex (TSC) and Lymphangioleiomyomatosis (LAM)